In VitroandIn VivoActivities of the Nitroimidazole TBA-354 against Mycobacterium tuberculosis
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چکیده
منابع مشابه
In vitro and in vivo activities of the nitroimidazole TBA-354 against Mycobacterium tuberculosis.
Nitroimidazoles are a promising new class of antitubercular agents. The nitroimidazo-oxazole delamanid (OPC-67683, Deltyba) is in phase III trials for the treatment of multidrug-resistant tuberculosis, while the nitroimidazo-oxazine PA-824 is entering phase III for drug-sensitive and drug-resistant tuberculosis. TBA-354 (SN31354[(S)-2-nitro-6-((6-(4-trifluoromethoxy)phenyl)pyridine-3-yl)methoxy...
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Tuberculosis (TB), resulting from infection with the bacterium Mycobacterium tuberculosis (M. tb), is a resurgent and major worldwide health problem. TB was the principal cause of early death in Europe in the 17th and 18th centuries, and was still a greatly feared disease in the 19th and early part of the 20th century (the “white plague”), when there was no active treatment available. Yet by th...
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Tuberculosis remains a major public health problem in both developing and developed countries. Drug-resistant tuberculosis is an increasing health problem and serious challenge to tuberculosis (TB) control programs. Information about the susceptibility pattern of Mycobacterium tuberculosis isolates against anti-tuberculosis drugs is an important aspect to TB control. The objectives of the s...
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Communications to the Editor admission for treatment ofsevere respiratory dysfunction. The time lapse between appropriate medical treatment and deterioration in our patients varied from two to seven months. Our patients also differed in having negative mycobacteria cultures in the sputum, bronchial washes and the endobronchial granuloma biopsy unlike the “reactivation” of tuberculosis which was...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2014
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.03823-14